Nandrolone decanoate (deca-durabolin) in primary Sjogren's syndrome: a double blind pilot study (Journal article)
Drosos, A. A./ van Vliet-Dascalopoulou, E./ Andonopoulos, A. P./ Galanopoulou, V./ Skopouli, F. N./ Moutsopoulos, H. M.
The efficacy and side-effects of Deca-Durabolin (DD) were tested, in a double blind fashion, in twenty female primary Sjogren's syndrome (1 degree SS) patients. Ten randomly assigned patients received DD (100 mg IM bi-weekly) for six months, and ten others placebo, for the same period. Analysis of the results revealed that the DD-treated patients showed a moderate improvement of subjective xerostomia, a significant decrease of the erythrocyte sedimentation rate (ESR), and an overall improvement of their feeling of well-being, -judged by themselves and the investigator subjectively-, when compared with the placebo group. All the sicca objective parameters (results of Schirmer's I test, slit lamp eye examination after rose bengal staining, stimulated parotid flow rate measurements and labial minor salivary gland histopathology) were not significantly altered in either group. The clinical side-effects were the expected ones, i.e. hirsutism, hoarseness and an increase in libido, more pronounced in the DD-treated group. At the end of the study, one DD-treated patient, developed a diffuse well-differentiated B-lymphocytic lymphoma, which regressed spontaneously three months later.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||Double-Blind Method,Hirsutism/chemically induced,Hoarseness/chemically induced,Humans,Libido/drug effects,Lymphocytes/pathology,Middle Aged,Nandrolone/adverse effects/*analogs & derivatives/therapeutic use,Pilot Projects,Salivary Glands/pathology,Sjogren's Syndrome/*drug therapy/pathology|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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