Near-absolute expression of the bcl-2 protein identifies a subgroup of stage II breast cancer patients with a most favorable outcome. Results of a clinicopathological study (Journal article)

Briasoulis, E./ Agnantis, N. J./ Zagorianakou, P./ Kamina, S./ Gorezi, M./ Pavlidis, N./ Bai, M.


The clinical relevance of quantitative assessment of tumor-tissue expression of the bcl-2 protein in operated stage II breast cancer was investigated in this study. Thirty-five cases were studied by immunohistochemistry for the expression of bcl-2 protein and analyzed for disease outcome. One fourth (25%) of the cases were negative and 57% demonstrated near-absolute expression of the bcl-2 protein. No association was found between immunohistochemical detection of the protein with age, hormonal receptor status and tumor grading other than between bcl-2 and estrogen receptor expression (p=0.01). An impressively positive impact of near-absolute expression of bcl-2 on clinical outcome was identified. Our results provide evidence that quantitative assessment of bcl-2 expression constitutes a new approach in early breast cancer with potential clinical implications. We consider that molecular sub-staging of patients with stage II breast cancer by level of bcl-2 expression provides additional important prognostic information and prompts for investigation of its clinical significance on the issue of adjuvant systemic therapy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Breast Neoplasms/drug therapy/mortality/*pathology/surgery,Chemotherapy, Adjuvant,Disease-Free Survival,Female,Humans,Middle Aged,Neoplasm Staging,Predictive Value of Tests,Prognosis,Proto-Oncogene Proteins c-bcl-2/*analysis,Retrospective Studies,Survival Rate,Time Factors,Treatment Outcome
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19814
ISSN: 0392-9078
Link: http://www.ncbi.nlm.nih.gov/pubmed/11718212
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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