Nephrocalcinosis in Sjogren's syndrome: a late sequela of renal tubular acidosis (Journal article)

Moutsopoulos, H. M./ Cledes, J./ Skopouli, F. N./ Elisaf, M. S./ Youinou, P.


Sjogren's syndrome (SS) is an autoimmune exocrinopathy that develops into systemic autoimmune disease in 25% of patients, leading to general complications, one of which is kidney involvement. It presents mainly as interstitial nephritis, disclosed by hyposthenuria, distal renal tubular acidosis (RTA) and diabetes insipidus. We here describe five cases of SS with type-1 RTA (hyperchloraemic metabolic acidosis with an anion gap and alkaline urine pH) who developed nephrolithiasis, nephrocalcinosis and renal insufficiency. Hypercalciuria due to acidosis was the main nephrocalcinosis-prone factor in four patients; four subjects displayed diminished renal concentrating capacity, and two had hypokalaemia.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Acidosis, Renal Tubular/*complications/physiopathology,Adult,Female,Humans,Hypergammaglobulinemia/complications,Kidney Calculi/etiology,Middle Aged,Nephrocalcinosis/complications/*etiology,Sjogren's Syndrome/*complications/physiopathology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19802
ISSN: 0954-6820
Link: http://www.ncbi.nlm.nih.gov/pubmed/1865172
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2796.1991.tb00429.x/asset/j.1365-2796.1991.tb00429.x.pdf?v=1&t=h0m93sfi&s=aa172b105050eb08a275063abeac3c6a1f369c3d
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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