Octreotide in the treatment of refractory ascites of cirrhosis (Journal article)

Kalambokis, G./ Fotopoulos, A./ Economou, M./ Tsianos, E. V.

Dietary sodium restriction and diuretic treatment have been shown to be effective in the treatment of ascites in the majority of cirrhotic patients. However, approximately 5 to 10% of patients develop refractory ascites, which is defined as ascites that does not respond to intensive diuretic therapy (diuretic-resistant) or ascites that cannot be controlled because the patient develops diuretic-induced complications that prevent the use of an effective diuretic dose (diuretic-intractable). Current therapeutic approaches for refractory ascites include repeated large-volume paracentesis and transjugular intrahepatic portosystemic shunting. In the present report, subcutaneous octreotide treatment improved renal function and hemodynamics and diuretic response in two patients with refractory ascites in line with a marked decrease in renin and aldosterone secretion. We consider that octreotide could be of value in the management of refractory ascites in cirrhotic patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Ascites/*drug therapy,Female,Humans,Injections, Subcutaneous,Liver Cirrhosis/*complications,Male,Middle Aged,Octreotide/administration & dosage/*therapeutic use
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19661
ISSN: 0036-5521
Link: http://www.ncbi.nlm.nih.gov/pubmed/16373285
http://informahealthcare.com/doi/abs/10.1080/00365520510024043
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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