Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints (Journal article)

Bartkova, J./ Rezaei, N./ Liontos, M./ Karakaidos, P./ Kletsas, D./ Issaeva, N./ Vassiliou, L. V./ Kolettas, E./ Niforou, K./ Zoumpourlis, V. C./ Takaoka, M./ Nakagawa, H./ Tort, F./ Fugger, K./ Johansson, F./ Sehested, M./ Andersen, C. L./ Dyrskjot, L./ Orntoft, T./ Lukas, J./ Kittas, C./ Helleday, T./ Halazonetis, T. D./ Bartek, J./ Gorgoulis, V. G.

Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA replication stress, which leads to activation of the DNA damage checkpoint and thereby to apoptosis or cell cycle arrest, whereas a second barrier is mediated by oncogene-induced senescence. The relationship between these two barriers, if any, has not been elucidated. Here we show that oncogene-induced senescence is associated with signs of DNA replication stress, including prematurely terminated DNA replication forks and DNA double-strand breaks. Inhibiting the DNA double-strand break response kinase ataxia telangiectasia mutated (ATM) suppressed the induction of senescence and in a mouse model led to increased tumour size and invasiveness. Analysis of human precancerous lesions further indicated that DNA damage and senescence markers cosegregate closely. Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Cell Aging/*genetics,Cell Cycle Proteins/genetics,Cell Line,Cell Transformation, Neoplastic/*genetics,Cyclin E/genetics,Cyclin-Dependent Kinase Inhibitor p16/physiology,Dna,*DNA Damage,DNA Replication,Genes, mos,Humans,Mice,Neoplasm Invasiveness/genetics,Nuclear Proteins/genetics,*Oncogenes,Precancerous Conditions/genetics/pathology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19626
ISSN: 1476-4687
Link: http://www.ncbi.nlm.nih.gov/pubmed/17136093
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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