Oral pilocarpine for the treatment of ocular symptoms in patients with Sjogren's syndrome: a randomised 12 week controlled study (Journal article)

Tsifetaki, N./ Kitsos, G./ Paschides, C. A./ Alamanos, Y./ Eftaxias, V./ Voulgari, P. V./ Psilas, K./ Drosos, A. A.

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dc.contributor.authorTsifetaki, N.en
dc.contributor.authorKitsos, G.en
dc.contributor.authorPaschides, C. A.en
dc.contributor.authorAlamanos, Y.en
dc.contributor.authorEftaxias, V.en
dc.contributor.authorVoulgari, P. V.en
dc.contributor.authorPsilas, K.en
dc.contributor.authorDrosos, A. A.en
dc.date.accessioned2015-11-24T19:00:45Z-
dc.date.available2015-11-24T19:00:45Z-
dc.identifier.issn0003-4967-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19588-
dc.rightsDefault Licence-
dc.subjectAdministration, Oralen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMiddle Ageden
dc.subjectMiotics/*administration & dosage/adverse effectsen
dc.subjectOphthalmic Solutions/administration & dosageen
dc.subjectPilocarpine/*administration & dosage/adverse effectsen
dc.subjectSjogren's Syndrome/*drug therapyen
dc.titleOral pilocarpine for the treatment of ocular symptoms in patients with Sjogren's syndrome: a randomised 12 week controlled studyen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14644860-
heal.identifier.secondaryhttp://ard.bmj.com/content/62/12/1204.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2003-
heal.abstractOBJECTIVE: To evaluate the efficacy and side effects of oral pilocarpine for the treatment of ocular symptoms in patients with primary Sjogren's syndrome (SS). METHODS: A 12 week, single centre, randomised controlled study was performed. Twenty nine patients were randomly assigned to receive oral pilocarpine (5 mg twice a day), 28 only artificial tears, and 28 inferior puncta occlusion. Patients receiving oral pilocarpine and those with inferior puncta occlusion also received artificial tears. Patients were evaluated at baseline and throughout the study for their subjective global assessment of dry eyes and for their objective assessment of dry eyes (Schirmer's-I test, rose bengal test, and imprint test). RESULTS: Patients taking oral pilocarpine had significant improvement in subjective global assessment of dry eyes, as was evaluated by improvement of >55 mm on a visual analogue scale (VAS) for responses to the eye questionnaire, compared with patients treated with artificial tears (p<0.001) and those with inferior puncta occlusion (p<0.05). Furthermore, patients receiving oral pilocarpine also showed greater objective improvement, as measured by the rose bengal test (p<0.05), while Schirmer's-I test showed no differences between the treated groups. Commonly reported adverse events were headache, increased sweating, nausea, and vomiting in the pilocarpine group, while one patient in the inferior puncta occlusion group had blepharitis and was withdrawn from the study. CONCLUSION: 10 mg of pilocarpine daily given to patients with SS for 12 weeks had a beneficial effect on subjective eye symptoms, as evaluated by improvement >55 mm on a VAS. Additionally, an improvement of rose bengal staining was noted, but an increase in tear production, as measured by the Schirmer-I test, was not substantiated.en
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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