Oxidative Stress Based-Biomarkers In Oral Carcinogenesis: How Far Have We Gone? (Journal article)

Hanafi, R./ Anestopoulos, I./ Voulgaridou, G. P./ Franco, R./ Georgakilas, A. G./ Ziech, D./ Malamou-Mitsi, V./ Pappa, A./ Panayiotidis, M. I.

Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19518
ISSN: 1875-5666
Link: http://www.ncbi.nlm.nih.gov/pubmed/22292437
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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