Phase II studies of Elsamitrucin in breast cancer, colorectal cancer, non-small cell lung cancer and ovarian cancer. EORTC Early Clinical Trials Group (Journal article)

Verweij, J./ Wanders, J./ Nielsen, A. L./ Pavlidis, N./ Calabresi, F./ ten Bokkel Huinink, W./ Bruntsch, U./ Piccart, M./ Franklin, H./ Kaye, S. B.

PURPOSE: To test the antitumor activity of Elsamitrucin in metastatic cancer of the breast, colon and rectum, non-small cell lung and ovary. PATIENTS AND METHODS: Eligibility required histologically proven cancer. Patients with colorectal or non-small cell lung cancer could not have received prior chemotherapy. Patients were entered if WHO PS was < or = 2 and organ functions were normal. Treatment consisted of Elsamitrucin 25 mg/m2/week given as a 5-10 min infusion for at least 3-6 weekly doses. RESULTS: One hundred and five patients entered the studies, 97 were eligible, 94 are evaluable for toxicity and 75 for response. Toxicity mainly consisted of mild nausea/vomiting, and less frequently reversible hepatotoxicity and malaise. No objective responses were seen. CONCLUSION: Elsamitrucin at this dose and schedule is not an active drug in metastatic breast cancer, colorectal cancer, non-small cell lung cancer or ovarian cancer.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,*Aminoglycosides,Anti-Bacterial Agents/adverse effects/*therapeutic use,Antibiotics, Antineoplastic/adverse effects/*therapeutic use,Breast Neoplasms/drug therapy,Carcinoma, Non-Small-Cell Lung/drug therapy,Colorectal Neoplasms/drug therapy,Drug Administration Schedule,Female,Follow-Up Studies,Humans,Lung Neoplasms/drug therapy,Male,Middle Aged,Neoplasms/*drug therapy,Ovarian Neoplasms/drug therapy
ISSN: 0923-7534
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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