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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/19308
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dc.contributor.authorPapadimitriou, C. S.en
dc.contributor.authorBai, M. K.en
dc.contributor.authorKotsianti, A. J.en
dc.contributor.authorCostopoulos, J. S.en
dc.contributor.authorHytiroglou, P.en
dc.date.accessioned2015-11-24T18:58:45Z-
dc.date.available2015-11-24T18:58:45Z-
dc.identifier.issn1042-8194-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19308-
dc.rightsDefault Licence-
dc.subjectAntigens, CD/analysis/biosynthesisen
dc.subjectAntigens, CD57/*analysis/*biosynthesisen
dc.subjectB-Lymphocytes/immunology/pathologyen
dc.subjectBase Sequenceen
dc.subjectCell Nucleus/pathology/ultrastructure/virologyen
dc.subjectCytoplasm/pathology/ultrastructure/virologyen
dc.subjectDNA Primersen
dc.subjectGene Expressionen
dc.subjectHerpesvirus 4, Human/genetics/*isolation & purificationen
dc.subjectHodgkin Disease/immunology/*pathologyen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectImmunohistochemistryen
dc.subjectImmunophenotyping/methodsen
dc.subjectLymph Nodes/immunology/pathology/virologyen
dc.subjectMolecular Sequence Dataen
dc.subjectPolymerase Chain Reactionen
dc.subjectReed-Sternberg Cells/immunology/*pathologyen
dc.subjectT-Lymphocytes/immunology/pathologyen
dc.titlePhenotype of Hodgkin and Sternberg-Reed cells and expression of CD57 (LEU7) antigenen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.3109/10428199509054763-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8750633-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate1995-
heal.abstractPossible associations between the immunophenotype of Hodgkin (H) and Sternberg-Reed (S-R) cells, the expression of CD57 (Leu 7) antigen, and the presence of Epstein-Barr virus (EBV) were investigated in lymph node specimens from 50 cases of Hodgkin's disease (HD), including 26 cases of mixed cellularity and 24 cases of nodular sclerosis. Tissues were fixed in 10% neutral formalin, or/and B5 solution. H and S-R cells were CD30+, CD15+ (85% of the cases) and LCA (CD45). A proportion of neoplastic cells positive for either T-cell markers (CD3) or B-cell markers (CD20) was observed in 10% and 34% of the cases, respectively. Membrane positivity for CD57 antigen was found in H and S-R cells in 10 cases (8 cases of mixed cellularity, and 2 cases of nodular sclerosis). Such immunopositivity was only observed in B5-fixed sections. No staining for CD57 antigen was identified in H and S-R cells of any case with CD20 positive neoplastic cells. H and S-R cells of both CD57-positive and CD57-negative cases were further studied by immunohistochemistry for LMP1, by in-situ hybridization for EBER and by polymerase chain reaction (PCR) for EBV-DNA. No association was identified between the expression of CD57 antigen and the presence of EBV sequences, transcripts or proteins. Our findings do not support a B-cell origin for H and S-R cells in CD57-positive cases of Hodgkin's disease and suggest that these neoplastic cells may be related to natural killer (NK) or T-cells expressing CD57 antigen.en
heal.journalNameLeuk Lymphomaen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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