Phosphate metabolism in the red cell of sick prematures (Journal article)

Cholevas, V./ Challa, A./ Lapatsanis, D./ Andronikou, S.

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dc.contributor.authorCholevas, V.en
dc.contributor.authorChalla, A.en
dc.contributor.authorLapatsanis, D.en
dc.contributor.authorAndronikou, S.en
dc.rightsDefault Licence-
dc.subjectAdenosine Triphosphate/blooden
dc.subjectAnalysis of Varianceen
dc.subjectDiphosphoglyceric Acids/blooden
dc.subjectGestational Ageen
dc.subjectInfant Fooden
dc.subjectInfant, Newbornen
dc.subjectInfant, Premature/*blooden
dc.subjectParenteral Nutrition, Totalen
dc.subjectPhosphates/administration & dosage/*pharmacologyen
dc.titlePhosphate metabolism in the red cell of sick prematuresen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractThe effect of different amounts of phosphorus supplementation on phosphate metabolism was studied in two groups of sick preterms (B and C) during the first week of life. Group B included prematures that started formula milk feeding from day 3 and group C neonates on total parenteral nutrition with phosphate supplementation for 7 days. Twelve healthy preterm neonates on formula milk feeding from day 2 (group A) were used as controls. On the 7th day of life all phosphate parameters measured in group C (plasma and red cell inorganic phosphate and erythrocyte ATP and 2,3-diphosphoglycerate) were found significantly lower than in the controls (1.60 +/- 0.07; 0.60 +/- 0.08; 1.45 +/- 0.09 and 4.42 +/- 0.18 vs. 2.05 +/- 0.10; 0.94 +/- 0.11; 1.69 +/- 0.07 and 6.24 +/- 0.42 mmol/l, respectively). The renal tubular reabsorption of phosphate was also lower in this group (86.8 +/- 3.2 vs. 97.3 +/- 1.0%). No significant differences were observed between groups B and A. Higher phosphorus intake that was better achieved through early milk feeding prevented phosphate depletion and the decline of 2,3-diphosphoglycerate in the erythrocytes even of sick neonates which in turn might help to improve tissue oxygenation. The amount of parenteral phosphate supplementation that could have beneficial effects on red cell phosphate parameters needs further investigation.en
heal.journalNameBone Mineren
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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