Platelet response to the aggregatory effect of platelet activating factor (PAF) ex vivo in patients with acute myocardial infarction (Journal article)

Tselepis, A. D./ Tsoukatos, D./ Droudes, C./ Donas, A./ Evangelou, A.


Platelets from patients with acute myocardial infarction exhibit an increased sensitivity to the aggregatory effect of PAF, in vitro, the first 48 h after the onset of the symptoms. This sensitivity, expressed as PAF EC50 values, seems to be transient after the 2 day period. Also, a remarkable decreased sensitivity to the inhibitory effect of PGI2 against the aggregation induced by PAF appears to the platelets of those patients the first hours after the onset of the symptoms, and persists for at least 14 days. Treatment of patients by drugs with a known inhibitory effect on platelet aggregation in vivo and in vitro (aspirin, nifedipine, indomethacin), does not influence the increase in platelet sensitivity to PAF, but inhibits the secondary aggregation induced by the released aggregating factors from the PAF activated platelets. The increase in platelet sensitivity to PAF is not unique to the AMI since it is also observed in patients with acute bacterial pneumonia. However, we cannot support the theory that it is a general phenomenon of acute tissue injury since it is general phenomenon of acute tissue injury since it is not observed in patients with acute muscular injury.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenosine Diphosphate/pharmacology,Aged,Aged, 80 and over,Drug Resistance,Epoprostenol/pharmacology,Humans,Male,Middle Aged,Myocardial Infarction/*blood,Platelet Activating Factor/*pharmacology,Platelet Aggregation/*drug effects,Time Factors
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19255
ISSN: 0014-2972
Link: http://www.ncbi.nlm.nih.gov/pubmed/1752288
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2362.1991.tb01400.x/asset/j.1365-2362.1991.tb01400.x.pdf?v=1&t=h04x4dna&s=691cc35bee31274695475204cb13977ca4fe7c5d
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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