Pneumothorax as a first manifestation of sarcoidosis (Journal article)

Froudarakis, M. E./ Bouros, D./ Voloudaki, A./ Papiris, S./ Kottakis, Y./ Constantopoulos, S. H./ Siafakas, N. M.


Pneumothorax is a rare manifestation of sarcoidosis, occurring usually late in the course of the disease. We report five cases of pneumothorax as a presenting manifestation of sarcoidosis. In two patients, thoracotomy showed extensive pleural infiltration by noncaseating granulomas. High-resolution CT scans showed cavitated subpleural nodules and subpleural bullae in one case. These findings support that necrosis of subpleural granulomas or rupture of a subpleural bullae, or both, are the mechanisms of pneumothorax in sarcoidosis. Three patients with a lung function impairment were treated with oral corticosteroids. One nontreated patient died due to progression of the disease.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Female,Follow-Up Studies,Humans,Male,Middle Aged,Pneumothorax/*etiology/radiography,Sarcoidosis, Pulmonary/*complications/radiography,Time Factors,Tomography, X-Ray Computed
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19237
ISSN: 0012-3692
Link: http://www.ncbi.nlm.nih.gov/pubmed/9228392
http://chestjournal.chestpubs.org/content/112/1/278.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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