Population pharmacokinetics and pharmacodynamics of paclitaxel and carboplatin in ovarian cancer patients: a study by the European organization for research and treatment of cancer-pharmacology and molecular mechanisms group and new drug development group (Journal article)

Joerger, M./ Huitema, A. D./ Richel, D. J./ Dittrich, C./ Pavlidis, N./ Briasoulis, E./ Vermorken, J. B./ Strocchi, E./ Martoni, A./ Sorio, R./ Sleeboom, H. P./ Izquierdo, M. A./ Jodrell, D. I./ Calvert, H./ Boddy, A. V./ Hollema, H./ Fety, R./ Van der Vijgh, W. J./ Hempel, G./ Chatelut, E./ Karlsson, M./ Wilkins, J./ Tranchand, B./ Schrijvers, A. H./ Twelves, C./ Beijnen, J. H./ Schellens, J. H.


PURPOSE: Paclitaxel and carboplatin are frequently used in advanced ovarian cancer following cytoreductive surgery. Threshold models have been used to predict paclitaxel pharmacokinetic-pharmacodynamics, whereas the time above paclitaxel plasma concentration of 0.05 to 0.2 micromol/L (t(C > 0.05-0.2)) predicts neutropenia. The objective of this study was to build a population pharmacokinetic-pharmacodynamic model of paclitaxel/carboplatin in ovarian cancer patients. EXPERIMENTAL DESIGN: One hundred thirty-nine ovarian cancer patients received paclitaxel (175 mg/m(2)) over 3 h followed by carboplatin area under the concentration-time curve 5 mg/mL*min over 30 min. Plasma concentration-time data were measured, and data were processed using nonlinear mixed-effect modeling. Semiphysiologic models with linear or sigmoidal maximum response and threshold models were adapted to the data. RESULTS: One hundred five patients had complete pharmacokinetic and toxicity data. In 34 patients with measurable disease, objective response rate was 76%. Neutrophil and thrombocyte counts were adequately described by an inhibitory linear response model. Paclitaxel t(C > 0.05) was significantly higher in patients with a complete (91.8 h) or partial (76.3 h) response compared with patients with progressive disease (31.5 h; P = 0.02 and 0.05, respectively). Patients with paclitaxel t(C > 0.05) > 61.4 h (mean value) had a longer time to disease progression compared with patients with paclitaxel t(C > 0.05) < 61.4 h (89.0 versus 61.9 weeks; P = 0.05). Paclitaxel t(C > 0.05) was a good predictor for severe neutropenia (P = 0.01), whereas carboplatin exposure (C(max) and area under the concentration-time curve) was the best predictor for thrombocytopenia (P < 10(-4)). CONCLUSIONS: In this group of patients, paclitaxel t(C > 0.05) is a good predictive marker for severe neutropenia and clinical outcome, whereas carboplatin exposure is a good predictive marker for thrombocytopenia.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Antineoplastic Agents/therapeutic use,Antineoplastic Combined Chemotherapy Protocols/therapeutic use,Area Under Curve,Carboplatin/*pharmacokinetics/*pharmacology,Disease Progression,Drug Design,Europe,Female,Humans,Kinetics,Neutropenia,Ovarian Neoplasms/*drug therapy/*genetics/*pathology,Paclitaxel/*pharmacokinetics/*pharmacology,Predictive Value of Tests,Thrombocytopenia,Treatment Outcome
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/19219
ISSN: 1078-0432
Link: http://www.ncbi.nlm.nih.gov/pubmed/17975154
http://clincancerres.aacrjournals.org/content/13/21/6410.full.pdf
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