Premature ovarian failure, endothelial dysfunction and estrogen-progestogen replacement (Journal article)

Kalantaridou, S. N./ Naka, K. K./ Bechlioulis, A./ Makrigiannakis, A./ Michalis, L./ Chrousos, G. P.

Cardiovascular disease, including coronary artery disease, stroke and peripheral vascular disease, is the leading cause of death among women. Vascular endothelial dysfunction is an early marker of atherosclerosis. Women with premature ovarian failure (or premature menopause) present an increased risk for cardiovascular disease, which might be attributed to the early onset of vascular endothelial dysfunction, associated with sex steroid deficiency. Cyclical estrogen and progestogen therapy has been shown to restore endothelial function in these young women. Further research is required to assess primarily the long-term effects of hormone replacement therapy on cardiovascular and overall prognosis in young women with premature ovarian failure, as well as the effects of different doses, duration and routes of hormone administration in these women.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Blood Vessels/drug effects/physiology,Cardiovascular Diseases/etiology,Endothelium, Vascular/*physiopathology,*Estrogen Replacement Therapy,Estrogens/pharmacology,Female,Humans,Postmenopause,Primary Ovarian Insufficiency/*drug therapy/*physiopathology,Progestins/*administration & dosage,Risk Factors
ISSN: 1043-2760
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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