Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis (Journal article)

Panoulas, V. F./ Douglas, K. M./ Milionis, H. J./ Stavropoulos-Kalinglou, A./ Nightingale, P./ Kita, M. D./ Tselios, A. L./ Metsios, G. S./ Elisaf, M. S./ Kitas, G. D.

OBJECTIVES: Rheumatoid arthritis (RA) associates with excessive cardiovascular morbidity and mortality. Hypertension (HT) contributes significantly to the development of cardiovascular disease (CVD). Little is known about the factors that influence blood pressure (BP) in patients with RA. In this study, we assessed the prevalence of HT in a secondary care cohort of RA patients, and aimed to identify factors associated with its presence and inadequate control. METHODS: A total of 400 consecutive RA patients were studied. HT was defined as systolic BP >/=140 mmHg and/or diastolic BP >/=90 mmHg or current use of antihypertensive drugs. The association of HT with several demographic and RA-related factors, comorbidities and drugs was evaluated using logistic regression. RESULTS: HT was present in 282 (70.5%) patients. Of those, 171 (60.6%) received anti-hypertensive therapy, but 111 (39.4%) remained undiagnosed. Of those treated, only 37/171 (21.8%) were optimally controlled. Multivariable logistic regression revealed age (OR = 1.054, CI: 1.02 to 1.07, P = 0.001), body mass index [BMI (OR = 1.06, CI: 1.003-1.121, P = 0.038)] and prednisolone use (OR = 2.39, CI: 1.02-5.6, P = 0.045) to be independently associated with the presence of HT. BMI (OR = 1.11, CI: 1.02-1.21, P = 0.002) and the presence of CVD (OR = 4.01, CI: 1.27-12.69, P = 0.018) associated with uncontrolled HT. CONCLUSIONS: HT is highly prevalent in RA, under-diagnosed particularly in the young, and under-treated particularly in old RA patients with CVD. RA patients receiving steroids should be specifically targeted for screening and treatment; those with any cardiovascular comorbidity may require particularly aggressive monitoring and treatment strategies.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Age Factors,Aged,Antihypertensive Agents/therapeutic use,Antirheumatic Agents/therapeutic use,Arthritis, Rheumatoid/*complications/drug therapy/epidemiology,Cross-Sectional Studies,England/epidemiology,Female,Humans,Hypertension/drug therapy/epidemiology/*etiology,Male,Middle Aged,Prevalence,Risk Factors,Severity of Illness Index
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19109
ISSN: 1462-0324
Link: http://www.ncbi.nlm.nih.gov/pubmed/17704521
http://rheumatology.oxfordjournals.org/content/46/9/1477.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Panoulas-2007-Prevalence and assoc.pdf120.03 kBAdobe PDFView/Open    Request a copy


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/19109
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.