Prognostic factors in Greek patients with small cell lung cancer (SCLC). A Hellenic Cooperative Oncology Group study (Journal article)

Christodolou, C./ Pavlidis, N./ Samantas, E./ Fountzilas, G./ Kouvatseas, G./ Pagdatoglou, K./ Palamidas, F./ Nikolaidis, C./ Angelidou, M./ Kalofonos, H. P./ Kosmidis, P./ Skarlos, D. V.

BACKGROUND: Prognostic factors among Greek patients with SCLC were evaluated. PATIENTS AND METHODS: Data from 516 patients with SCLC treated by the Hellenic Cooperative Oncology Group were analyzed. Multivariate analysis was performed. RESULTS: Complete response (CR) was achieved in 26.8% and partial response in 40.1% of patients. The median duration of response was 7.4 months, the median survival 10.5 months and the 2-year survival rate 12%. The stage of the disease was a dominant prognostic factor for survival and response. PS 0-1 was a major prognostic factor for survival, duration of response and CR. Female gender was a favorable predictor for CR. Superior vena cava syndrome was a poor prognostic factor for survival and duration of response. Weight loss and age > or = 60 were poor predictors for response. The sites of metastases affected survival, duration of response and response. Normal alkaline phosphatase was a favorable prognostic factor for survival, duration of response and response. Normal lactate dehydrogenase and thoracic irradiation were favorable prognostic factors for survival and duration of response.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Aged, 80 and over,Antineoplastic Combined Chemotherapy Protocols/therapeutic use,Carboplatin/administration & dosage,Carcinoma, Small Cell/complications/*drug therapy/pathology/*radiotherapy,Clinical Trials as Topic,Ethnic Groups,Etoposide/administration & dosage,Female,Greece,Humans,Lung Neoplasms/complications/*drug therapy/pathology/*radiotherapy,Male,Middle Aged,Multivariate Analysis,Neoplasm Staging,Prognosis,Risk Factors,Sex Factors,Superior Vena Cava Syndrome/complications,Survival Rate,Treatment Outcome
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/19025
ISSN: 0250-7005
Link: http://www.ncbi.nlm.nih.gov/pubmed/12552988
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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