Prospective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastases (Journal article)

Pamecha, V./ Nedjat-Shokouhi, B./ Gurusamy, K./ Glantzounis, G. K./ Sharma, D./ Davidson, B. R.

BACKGROUND: Liver resection is contraindicated in patients with multiple bilobar colorectal liver metastases because of the small liver remnant. An alternative strategy which may be curative is a two-stage hepatectomy in which the cancer is resected from one lobe and regeneration allowed prior to contralateral lobe resection. OBJECTIVE: To assess the feasibility, risks, and outcomes in a prospectively applied strategy for two-stage hepatectomy. METHODS: Over a 6-year period, 14 of 280 patients undergoing liver resection for colorectal liver metastases (5%) were considered for two-stage hepatectomy. Surgery was combined with chemotherapy in all (n = 14) and portal vein embolisation (PVE) selectively (n = 5). Median follow-up was 43 months. RESULTS: Both stages were completed in 11 of 14 patients (78%). There were no deaths. Post-operative complication rates were 0% (1st hepatectomy) and 27% (2nd hepatectomy). The 5-year survival after the second hepatectomy was 50%. The mean disease-free survival was 25 +/- 7.5 months. CONCLUSION: Two-stage hepatectomy combined with systemic chemotherapy and PVE can produce long-term survival in patients with multiple bilobar colorectal liver metastases.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Antineoplastic Combined Chemotherapy Protocols/therapeutic use,Chemotherapy, Adjuvant,Colorectal Neoplasms/*pathology/*therapy,*Embolization, Therapeutic,Female,Hepatectomy/*methods,Humans,Liver Neoplasms/*secondary/surgery/*therapy,Male,Middle Aged,*Portal Vein,Prospective Studies,Survival Analysis,Treatment Outcome
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18967
ISSN: 1421-9883
Link: http://www.ncbi.nlm.nih.gov/pubmed/19033722
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