Use of interferon-gamma release assay for latent tuberculosis infection screening in older adults exposed to tuberculosis in a nursing home (Journal article)

Katsenos, S./ Nikolopoulou, M./ Gartzonika, C./ Manda-Stachouli, C./ Gogali, A./ Grypaiou, C./ Mavridis, A./ Constantopoulos, S. H./ Daskalopoulos, G.

OBJECTIVES: To assess the additive value of a newly marketed interferon-gamma release assay, QuantiFERON-TB Gold In-Tube (QFT-GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home. DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT-GIT in TST-negative people (TST< 5 mm). SETTING: A private nursing home. PARTICIPANTS: Seventy-seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home. MEASUREMENTS: Comparison of TST and QFT-GIT in older adults who have been exposed to TB. RESULTS: For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT-GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT-GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%. CONCLUSION: QFT-GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged, 80 and over,Cross Infection/diagnosis,Female,Humans,Interferon-gamma/*diagnostic use,Latent Tuberculosis/*diagnosis,Male,Mass Screening/*methods,*Nursing Homes,Tuberculin Test/*methods
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18887
ISSN: 1532-5415
Link: http://www.ncbi.nlm.nih.gov/pubmed/21517785
http://onlinelibrary.wiley.com/store/10.1111/j.1532-5415.2011.03367.x/asset/j.1532-5415.2011.03367.x.pdf?v=1&t=h0p345tj&s=2b14964563701bf69e51d752a1b371c2273730e3
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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