Relationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosus (Journal article)

Dueymes, M./ Barrier, J./ Besancenot, J. F./ Cledes, J./ Conri, C./ Dien, G./ Drosos, A. A./ Dueymes, J. M./ Galanaud, P./ Grobois, B./ et al.,


IgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average of 64 +/- 27% was IgG1, 16 +/- 22% IgG2, 16 +/- 19% IgG3 and 4 +/- 10% IgG4. The rank order or frequency was IgG1, IgG3, IgG2 and IgG4 in patients with musculoskeletal involvement; IgG1, IgG2, IgG3 and IgG4 in those with renal complications; IgG3, IgG1, IgG2 and IgG4 in those with cutaneous involvement; and IgG1, IgG3, IgG2 and IgG4 in those with hematological manifestations. Interleukin-4 (IL-4) was detectable in 17 of 36 selected patients, as opposed to 1 of 40 normal controls. The percentage of the total autoantibody contributed by IgG1 was significantly higher (p < 0.03) in these patients than in the remainder with undetectable levels of IL-4.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Aged, 80 and over,Antibodies, Antinuclear/*blood,DNA/*immunology,Female,Humans,Immunoglobulin Isotypes/classification,Interleukin-4/*blood,Lupus Erythematosus, Systemic/blood/*immunology,Male,Middle Aged
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18691
ISSN: 1018-2438
Link: http://www.ncbi.nlm.nih.gov/pubmed/8353462
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000236484
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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