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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Boki, K. A. | en |
| dc.contributor.author | Katsorida, M. E. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.contributor.author | Skopouli, F. N. | en |
| dc.contributor.author | Boletis, J. N. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T18:54:24Z | - |
| dc.date.available | 2015-11-24T18:54:24Z | - |
| dc.identifier.issn | 0085-2538 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18680 | - |
| dc.rights | Default Licence | - |
| dc.subject | Cohort Studies | en |
| dc.subject | Cyclophosphamide/*therapeutic use | en |
| dc.subject | Humans | en |
| dc.subject | Lupus Nephritis/*drug therapy | en |
| dc.subject | Recurrence | en |
| dc.subject | Remission Induction | en |
| dc.title | Remission, relapse, and re-remission of proliferative lupus nephritis treated with cyclophosphamide | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1046/j.1523-1755.2000.00832.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10620207 | - |
| heal.identifier.secondary | http://www.nature.com/ki/journal/v57/n1/pdf/4491315a.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2000 | - |
| heal.abstract | Remission, relapse, and re-remission of proliferative lupus nephritis treated with cyclophosphamide. BACKGROUND: Long-term intravenous cyclophosphamide (IVC) in combination with corticosteroids is standard therapy for proliferative lupus nephritis, but it has limitations. There are few data on long-term remission rates, predictors of relapse, and the ability to achieve a second remission with currently recommended IVC regimens. METHODS: A cohort of 85 patients with proliferative lupus glomerulonephritis (focal N = 33, diffuse N = 52) treated with IVC was assembled in three institutions. Timing and predictors of remission, relapse, and re-remission were evaluated with Kaplan-Meier analyses and Cox models. RESULTS: The median time to remission was 10 months, whereas an estimated 22% of patients had not remitted after 2 years. The median time to relapse among 63 patients who had achieved remission was 79 months. In multivariate models, adverse predictors of remission were a delay in the initiation of therapy from the time nephritis was clinically diagnosed [hazard ratio (HR) 0.58, P = 0. 063] and a higher amount of proteinuria (HR 0.86 per 1 g/24 hours, P = 0.014). Predictors of earlier relapse for patients entering remission included a longer time to remission (HR 1.029 per month, P = 0.025), a history of central nervous system involvement (HR 8.41, P = 0.002), and World Health Organization histology (P = 0.01). Among the 23 patients who relapsed during follow-up, the median time to re-remission was 32 months, and with three exceptions, all patients took substantially longer time to remit the second time compared with their first remission (P = 0.01). The time to re-remission was longer in patients who had taken longer to remit the first time (HR 0.979 per month, P = 0.16), in patients who had relapsed earlier after the first remission (HR 1.071 per month, P = 0.002), and in those with evidence of chronicity in the original kidney biopsy (P = 0.015). CONCLUSIONS: Prolonged courses with a cumulative risk of toxicity are needed to achieve remission in many first-treated patients and in most patients treated for a second time. The optimal management of patients with identified adverse predictors of response needs further study. | en |
| heal.journalName | Kidney Int | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ioannidis-2000-Remission, relapse.pdf | 221.22 kB | Adobe PDF | View/Open Request a copy |
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