Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC) (Journal article)

Georgolios, A./ Batistatou, A./ Manolopoulos, L./ Charalabopoulos, K.

E- cadherin is a member of the cadherin superfamily known as the main mediator of the cell- cell calcium dependent adhesion interactions. Research evidence also yields to this adhesion molecule an important role in carcinogenesis and tumor progression. This review focuses on the differential expression of E- cadherin in the various anatomic sites of the human body where HNSCC arises. Controversies in the results of various studies are discussed and possible prospects for application of all this developing knowledge to prognosis and therapy of the disease are briefly mentioned.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Cadherins/*biosynthesis/*physiology,Carcinoma, Squamous Cell/*metabolism/pathology/therapy,Disease Progression,*Gene Expression Regulation, Neoplastic,Head and Neck Neoplasms/*metabolism/pathology/therapy,Humans,Prognosis
ISSN: 0392-9078
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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