Rosuvastatin treatment is associated with an increase in insulin resistance in hyperlipidaemic patients with impaired fasting glucose (Journal article)

Kostapanos, M. S./ Milionis, H. J./ Agouridis, A. D./ Rizos, C. V./ Elisaf, M. S.

AIM OF THE STUDY: The increase in physician-reported diabetes following rosuvastatin treatment in the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin study has raised concerns whether this statin exerts a detrimental effect on glucose metabolism. We assessed the effect of rosuvastatin treatment across dose range on glucose homeostasis in hyperlipidaemic patients with impaired fasting glucose (IFG), who are at high risk to develop diabetes mellitus. METHODS: The medical records of 72 hypelipidaemic patients with IFG on rosuvastatin 10 (RSV10 group), 20 (RSV20 group) and 40 mg/day (RSV40 group) were reviewed. The median follow up was 12.4 weeks. At the first visit, prior to rosuvastatin prescription and at the latest visit, serum lipid profile and indices of glucose metabolism, including fasting glucose, insulin and HOmeostasis Model Assessment (HOMA(IR)) index levels, were assessed. RESULTS: Rosuvastatin treatment improved lipid profile and was associated with a dose-dependent significant increase in HOMA(IR) values by 25.4%, 32.3% and 44.8% at the dose of 10, 20 and 40 mg/day (p < 0.01 for all, p < 0.05 for the comparison between groups), respectively, mirrored by correspondent increase in plasma insulin levels [by 21.7%, 25.7% and 46.2% in the RSV10, RSV20 and RSV40 group (p < 0.001 for all) respectively]. Baseline HOMA(IR) levels was the most important contributor (R(2) = 68.1%, p < 0.001), followed by the dose of rosuvastatin treatment (R(2) = 23.7%, p < 0.01), in a model that explained 91.8% of the variability in HOMA(IR) increase. CONCLUSION: In patients with IFG and hyperlipidaemia, rosuvastatin treatment was associated with a dose-dependent increase in insulin resistance.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Blood Glucose/*drug effects,Fasting/blood,Female,Fluorobenzenes/*adverse effects,Humans,Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects,Hyperlipidemias/*drug therapy,Hypolipidemic Agents/*adverse effects,Insulin Resistance/*physiology,Male,Middle Aged,Pyrimidines/*adverse effects,Sulfonamides/*adverse effects,Young Adult
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18489
ISSN: 1742-1241
Link: http://www.ncbi.nlm.nih.gov/pubmed/19691613
http://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2009.02101.x/asset/j.1742-1241.2009.02101.x.pdf?v=1&t=h0t3edsi&s=2456e11cfec3ce49e94e1ea609c2fd242d7e923d
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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