Second malignancies following treatment for Hodgkin's disease: a Greek experience (Journal article)

Economopoulos, T./ Stathakis, N./ Alexopoulos, C./ Pavlidis, N./ Constantinidou, M./ Briassoulis, E./ Papageorgiou, E./ Dervenoulas, J./ Pappa, V./ Vaslamatzis, M./ et al.,

The risk and the type of second malignancies (SM) developing in 217 treated Hodgkin's disease (HD) patients were studied. The median age of the patients was 35 years (range 14-83) and the M/F ratio 1.8. Treatment consisted of radiotherapy alone (24 patients, 11%), chemotherapy alone (96 patients, 44.3%), or a combination of both modalities (43 patients, 19.8%), while 54 patients (24.9%) received salvage treatment. The median follow-up time was 67 months (range 12-224). Ten patients developed a SM with a 5-year and 10-year actuarial risk of 3.3% and 5.4%, respectively. There were 3 cases of ANLL and MDS (actuarial risk of 2.4% at 6 years), 1 case of non-Hodgkin's lymphoma and 6 cases of solid tumors (actuarial risk of 2.4% at 6 years). The risk of developing SM was higher in males and older patients (> 40 years). SM represent a serious late side effect of successful treatment for HD. The possibility of developing a SM must be taken into consideration in the initial treatment of the disease.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Aged, 80 and over,Female,Follow-Up Studies,Greece,Hodgkin Disease/pathology/*therapy,Humans,Male,Middle Aged,Neoplasms, Second Primary/*etiology
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18437
ISSN: 0390-6078
Link: http://www.ncbi.nlm.nih.gov/pubmed/7926979
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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