Selenium and haemodialysis: serum selenium levels in healthy persons, non-cancer and cancer patients with chronic renal failure (Journal article)

Kallistratos, G./ Evangelou, A./ Seferiadis, K./ Vezyraki, P./ Barboutis, K.

In 40 healthy persons, 11 nondialyzed uremic patients and 27 dialyzed uremic patients, of whom 4 also had cancer, the selenium concentration in serum was determined. The mean serum selenium concentration in healthy persons was 13.6 +/- 0.8 micrograms/dl, in nondialyzed patients 11.9 +/- 1.9 micrograms/dl and in dialyzed uremic patients 11.3 +/- 1.0 micrograms/dl. There was a significant statistical difference between healthy persons and uremic patients (p less than 0.001), but not between dialyzed and nondialyzed uremic patients. The subgroup of cancer patients on hemodialysis also had low serum selenium concentrations. The possible role of low selenium levels as one of the factors responsible for the increased incidence of malignancy in patients with chronic renal failure is supported by several facts such as: low serum selenium levels detected in patients with malignant diseases; the higher cancer incidence in inhabitants of low-selenium areas, and the known ability of selenium to inhibit many types of experimental carcinogenesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Female,Glomerulonephritis/blood,Humans,Kidney Failure, Chronic/*blood,Male,Middle Aged,Neoplasms/*blood,Nephritis/blood,Polycystic Kidney Diseases/blood,Pyelonephritis/blood,*Renal Dialysis,Selenium/*blood,Uremia/blood
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18409
ISSN: 0028-2766
Link: http://www.ncbi.nlm.nih.gov/pubmed/4058621
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000183586
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
There are no files associated with this item.


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/18409
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.