Variation of inflammatory indexes after electrical cardioversion of persistent atrial fibrillation. Is there an association with early recurrence rates? (Journal article)

Korantzopoulos, P./ Kolettis, T. M./ Kountouris, E./ Siogas, K./ Goudevenos, J. A.

Inflammation has been recently implicated in the pathophysiology of atrial fibrillation (AF). The aim of this study was to examine the variation of inflammatory indexes during the first week after successful electrical cardioversion of persistent AF. Successive measurements of white blood cell (WBC) count, C-reactive protein (CRP) and fibrinogen levels were performed in 30 cardioverted patients. At the end of the 7-day follow-up period, AF had recurred in 30% of patients. A significant variance was found in serial measurements of fibrinogen levels in the two groups (non-relapse and relapse, p = 0.005). Fibrinogen levels increased significantly in patients who relapsed into AF, but remained stable in patients who remained in sinus rhythm. In the latter patients, CRP values tended to decrease post-cardioversion, but WBC count was significantly lower (p < 0.001) on the 7th day (6083 +/- 1335), compared with baseline values (6648 +/- 1395). The variation of inflammatory indices post-cardioversion might have prognostic implications with regard to sinus rhythm maintenance.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Analysis of Variance,Atrial Fibrillation/*blood/*therapy/ultrasonography,Biological Markers/blood,C-Reactive Protein/analysis,Echocardiography,*Electric Countershock,Female,Fibrinogen/analysis,Humans,Leukocyte Count,Male,Prospective Studies,Recurrence
ISSN: 1368-5031
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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