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  4. Τμήμα Ιατρικής
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/18375
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dc.contributor.authorChaliasos, N.en
dc.contributor.authorChalla, A.en
dc.contributor.authorHatzimichael, E.en
dc.contributor.authorKoutsouka, F.en
dc.contributor.authorBourantas, D.en
dc.contributor.authorVlahos, A. P.en
dc.contributor.authorSiamopoulou, A.en
dc.contributor.authorBourantas, K. L.en
dc.contributor.authorMakis, A.en
dc.date.accessioned2015-11-24T18:52:15Z-
dc.date.available2015-11-24T18:52:15Z-
dc.identifier.issn1421-9662-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18375-
dc.rightsDefault Licence-
dc.subjectAdipokines/*blooden
dc.subjectAdiponectin/*blooden
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgingen
dc.subjectBiological Markers/blooden
dc.subjectBlood Transfusionen
dc.subjectBody Mass Indexen
dc.subjectC-Reactive Protein/metabolismen
dc.subjectChelating Agents/therapeutic useen
dc.subjectChilden
dc.subjectEndothelin-1/blooden
dc.subjectEndothelin-3/blooden
dc.subjectFemaleen
dc.subjectFerritins/blooden
dc.subjectHumansen
dc.subjectInflammation/*blooden
dc.subjectIntercellular Adhesion Molecule-1/blooden
dc.subjectLeptin/blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectVascular Cell Adhesion Molecule-1/blooden
dc.subjectbeta-Thalassemia/*blood/drug therapy/genetics/immunologyen
dc.titleSerum adipocytokine and vascular inflammation marker levels in Beta-thalassaemia major patientsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1159/000320274-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21042009-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000320274&Ausgabe=254671&ProduktNr=223829&filename=000320274.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractBACKGROUND/AIM: The adipocytokines leptin and adiponectin represent a critical link between metabolism, immunity and chronic inflammation. A chronic vascular inflammatory state plays an important role in the pathophysiology of thalassaemia. We aimed to analyze the levels of these adipocytokines and determine any possible correlations with disease severity or vascular inflammation markers in beta-thalassaemia. METHODS: Serum leptin, adiponectin, high-sensitivity C-reactive protein, endothelins, vascular adhesion molecule-1, intracellular adhesion molecule-1 and L- and E-selectin were measured in 28 beta-thalassaemia patients and compared with levels in healthy controls. RESULTS: Leptin was significantly lower in patients compared to controls (2.23 +/- 1.8 vs. 10.24 +/- 5.78 mug/l; p = 0.0018), whereas adiponectin was elevated (11.75 +/- 5.67 vs. 6.83 +/- 2.75 mug/l; p = 0.009). For both adipocytokines, no correlations were found with characteristics such as age, gender, type of chelation, body mass index z score or haemoglobin. Leptin, but not adiponectin, was negatively correlated with ferritin (p = 0.032, r = -0.61). No correlations were found between leptin and the inflammation markers. However, adiponectin was positively correlated with endothelin-1 (p = 0.022, r = 0.63). CONCLUSIONS: Serum leptin is low in beta-thalassaemia, perhaps due to the toxic effect of iron overload on adipose tissue. Paradoxically, adiponectin levels are high and positively correlated with endothelin-1, raising questions about the pro- or anti-inflammatory role of this adipocytokine in beta-thalassaemia.en
heal.journalNameActa Haematolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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