Serum and tissue selenium levels in gastric cancer patients and correlation with CEA (Journal article)

Charalabopoulos, K./ Kotsalos, A./ Batistatou, A./ Charalabopoulos, A./ Peschos, D./ Vezyraki, P./ Kalfakakou, V./ Metsios, A./ Charalampopoulos, A./ Macheras, A./ Agnantis, N./ Evangelou, A.

BACKGROUND: An inverse relationship between selenium (Se) intake and cancer mortality is evident in humans. MATERIALS AND METHODS: In eighty patients who had been operated on for primary gastric cancer, serum Se and carcinoembryonic antigen (CEA) levels were measured preoperatively using a fluorometric and immunoradiometric assay (IRMA), respectively. RESULTS: The serum Se levels were 43+/-6.3 microg l(-1) in the patient group and 68.7+/-4.5 microg l(-1) in healthy individuals (p<0.001). The serum CEA was 12+/-1.9 U ml(-1) in the gastric cancer patients and 2.1 U ml(-1) in the control group (p<0.001). The Se tissue concentrations were 2,640+/-220 mg g(-1) in excised neoplastic tissue and 685+/-115 mg g(-1) in non-neoplastic tissue (p<0.001). An inverse correlation between Se and CEA serum levels was found (r=-0.782). There was no correlation between serum/tissue Se concentration and disease stage/histological type or gender in the patient group.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adenocarcinoma/*metabolism/secondary,Carcinoembryonic Antigen/*blood,Case-Control Studies,Female,Fluorometry,Humans,Immunoenzyme Techniques,Immunoradiometric Assay,Intestinal Neoplasms/*metabolism/pathology,Male,Middle Aged,Neoplasm Staging,Prognosis,Selenium/*metabolism,Stomach Neoplasms/*metabolism/pathology,Tumor Markers, Biological/*blood
ISSN: 1791-7530
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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