Serum levels of soluble fas in patients with multinodular goiter (Journal article)

Andrikoula, M./ Kolaitis, N./ Vartholomatos, G./ Tsatsoulis, A.


OBJECTIVE: Fas is a cell-surface receptor responsible for induction of apoptosis in human thyrocytes upon interaction with Fas Ligand. Fas protein expression on thyroid cells and Fas-mediated apoptosis is decreased in multinodular goiter (MNG) resulting in thyroid cell proliferation. The soluble form of Fas (sFas) produced by alternative mRNA splicing may inhibit Fas-Fas Ligand binding and apoptosis. The aim of this study was to examine whether sFas is differentially expressed in multinodular goiter (MNG), which is associated with decreased Fas-mediated apoptosis. METHOD: We determined serum sFas levels using enzyme-linked immunosorbent assay (ELISA) in 42 patients with MNG and 23 normal controls. RESULTS: Serum sFas levels were increased in patients with MNG (7.47 +/- 2.55 ng/ml) compared to normal controls (2.26 +/- 0.9 ng/ml). Levels of sFas were not significantly correlated with age, sex or clinical parameters, such as serum levels of FT4 or TSH. DISCUSSION: Increased sFas in MNG may indicate increased expression of alternatively spliced Fas mRNA variant and decreased expression of cell-surface Fas protein, and may enhance thyroid cell proliferation by protecting thyroid cells from Fas-mediated apoptosis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Alternative Splicing,Antigens, CD95/*blood,Enzyme-Linked Immunosorbent Assay,Female,Goiter, Nodular/*blood,Humans,Male,Middle Aged,Protein Isoforms/blood,Thyrotropin/blood,Thyroxine/blood,Triiodothyronine/blood,Young Adult
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18357
ISSN: 1532-4311
Link: http://www.ncbi.nlm.nih.gov/pubmed/19811416
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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