Serum soluble interleukin-2 receptors in epithelial ovarian cancer patients (Journal article)

Pavlidis, N. A./ Bairaktari, E./ Kalef-Ezra, J./ Nicolaides, C./ Seferiadis, C./ Fountzilas, G.


The levels of soluble interleukin-2 receptors (sIL-R2) were measured in the serum of 52 patients with epithelial ovarian carcinoma as well as in 25 age and sex-matched normal controls. The mean serum level of sIL-R2 was increased in 37 patients (71.2%). Comparison of these levels to those of normal controls showed a highly statistically significant difference (p < 0.001). Serum sIL-R2 levels were not related to histology, clinical stage or the presence of ascites (p = 0.58, p = 0.32 and p = 0.67, respectively), nor did they follow disease activity or response to chemotherapy. However, patients with higher pretreatment sIL-2R levels (more than 1200 U/ml) were found to have a longer survival (p < 0.02), possibly explained by the presence of activated lymphocytes and a better immune surveillance. We conclude that the serum level of sIL-R2: a) is elevated in ovarian cancer patients, b) has no relationship with histological subtypes, tumor burden or the presence of ascites, c) cannot serve as a valuable tumor marker for the monitoring of patient treatment, and d) has a prognostic value for survival.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Ascites/metabolism,CA-125 Antigen/blood,Carcinoma/blood/drug therapy/*immunology/mortality,Female,Humans,Middle Aged,Neoplasm Proteins/*blood,Ovarian Neoplasms/blood/drug therapy/*immunology/mortality,Prognosis,Receptors, Interleukin-2/*analysis,Retrospective Studies,Solubility,Treatment Outcome,Tumor Markers, Biological/*blood
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18346
ISSN: 0393-6155
Link: http://www.ncbi.nlm.nih.gov/pubmed/7561242
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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