Serum tumor markers in non-Hodgkin's lymphomas and chronic lymphocytic leukemia (Journal article)

Pavlidis, A. N./ Kalef-Ezra, J./ Bourantas, L. C./ Lambrou, A./ Mavridis, A.


The levels of soluble interleukin-2 receptors (sIL-2R), beta-2 microglobulin (beta-2M), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were measured in the serum of 50 previously untreated patients with non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL) as well as in 25 age and sex-matched normal controls. Compared to normal controls, mean serum levels of sIL-2R and beta-2M were significantly increased in both NHL and CLL (p < 0.001) while the increase in ESR and CRP was less marked (p < 0.01 and p < 0.05, respectively). Comparison of these tumor markers with histologic grading showed statistically significant differences only for CRP between low, intermediate and high-grade lymphomas (p < 0.001 and p < 0.05). More advanced stages exhibited higher mean values of all serum markers than early stages (p < 0.001 for sIL-2R, beta-2M and ESR and p < 0.05 for CRP). An association with the presence of b-symptoms was observed only for sIL-2R (p < 0.05). In addition, sIL-2R as well as beta-2M were able to predict time to progression in patients with diffuse large-cell lymphomas. We conclude that of the four tumor markers tested sIL-2R and beta-2M more frequently showed increased serum levels and were associated with clinical stage and/or presence of b-symptoms. Both sIL-2R and beta-2M were also found to have prognostic significance for survival.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Aged, 80 and over,*Blood Sedimentation,C-Reactive Protein/*analysis,Female,Humans,Leukemia, Lymphocytic, Chronic, B-Cell/*blood/mortality,Life Tables,Lymphoma, Non-Hodgkin/*blood/mortality/pathology,Male,Middle Aged,Neoplasm Proteins/*blood,Prognosis,Receptors, Interleukin-2/*analysis,Survival Analysis,Tumor Markers, Biological/*blood,beta 2-Microglobulin/*analysis
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18342
ISSN: 0393-6155
Link: http://www.ncbi.nlm.nih.gov/pubmed/8496627
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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