Severe muscle weakness due to hypokalemia as a manifestation of small-cell carcinoma (Journal article)

Konstantinidis, A./ Elisaf, M. S./ Panteli, K./ Constantopoulos, S.


We describe the case of a 56-year-old man with severe muscle weakness due to heavy hypokalemia (serum potassium 1.44 mmol/l) associated with inappropriate kaliuria and alkalemia. Subsequent investigation revealed the presence of ectopic ACTH hypersecretion due to a small-cell lung carcinoma. A significant clinical/laboratory improvement was achieved following chemotherapy-induced regression of the primary tumor. The profound hypokalemia was probably the result of cortisol hypersecretion, which in concert with the ACTH-induced decreased 11beta-hydroxysteroid dehydrogenase activity can exhibit an increased mineralocorticoid activity. In addition, other ACTH-dependent mineralocorticoids may play a contributory role in the development of severe hypokalemia.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: ACTH Syndrome, Ectopic/etiology,Antineoplastic Agents/therapeutic use,Carboplatin/therapeutic use,Carcinoma, Small Cell/*complications/drug therapy,Etoposide/therapeutic use,Humans,Hypokalemia/*etiology,Lung Neoplasms/*complications/drug therapy,Male,Middle Aged,Muscle Weakness/*etiology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18320
ISSN: 0025-7931
Link: http://www.ncbi.nlm.nih.gov/pubmed/10364746
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Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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