Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis (Journal article)

Taskapan, H./ Ersoy, F. F./ Passadakis, P. S./ Tam, P./ Memmos, D. E./ Katopodis, K. P./ Ozener, C./ Akcicek, F./ Camsari, T./ Ates, K./ Ataman, R./ Vlachojannis, J. G./ Dombros, N. A./ Utas, C./ Akpolat, T./ Bozfakioglu, S./ Wu, G./ Karayaylali, I./ Arinsoy, T./ Stathakis, C. P./ Yavuz, M./ Tsakiris, D. J./ Dimitriades, A. D./ Yilmaz, M. E./ Gultekin, M./ Oreopoulos, D. G.


The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers. METHOD: This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism. RESULTS: Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3. CONCLUSION: We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adult,Aged,Cross-Sectional Studies,Diabetic Nephropathies/therapy,Female,Humans,Kidney Failure, Chronic/*complications/etiology,Male,Middle Aged,Peritoneal Dialysis/*adverse effects,Vitamin D/blood,Vitamin D Deficiency/*complications/epidemiology/*etiology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18317
ISSN: 0301-0430
Link: http://www.ncbi.nlm.nih.gov/pubmed/17063991
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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