Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage (Journal article)
Dasoula, A./ Kalantaridou, S./ Sotiriadis, A./ Pavlou, M./ Georgiou, I./ Paraskevaidis, E./ Makrigiannakis, A./ Syrrou, M.
OBJECTIVES: To investigate if skewed X-chromosome inactivation (XCI) is associated with unexplained recurrent miscarriage (RM) in Greek women. METHODS: This was a prospective case-control study. A methylation-sensitive assay was used to investigate the X-inactivation pattern of women with unexplained RM and controls. RESULTS: Fifty-six of the 74 patients (75.7%) and 55 of 80 controls (68.8%) were informative. Among the informative cases, 6/56 (10.7%) women showed extreme XCI (>90%) and among the informative controls, 2/55 (3.6%) showed extreme XCI. CONCLUSIONS: In the present study, women with unexplained RM showed a statistically nonsignificant increase in skewed XCI prevalence (10.7%) compared with control women (3.6%; p = 0.271).
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής|
|Keywords:||Abortion, Habitual/*genetics,Adult,Case-Control Studies,Female,Greece,Heterozygote,Humans,Male,Odds Ratio,Polymerase Chain Reaction,Pregnancy,Prospective Studies,Receptors, Androgen/genetics,*X Chromosome Inactivation|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
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