Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage (Journal article)

Dasoula, A./ Kalantaridou, S./ Sotiriadis, A./ Pavlou, M./ Georgiou, I./ Paraskevaidis, E./ Makrigiannakis, A./ Syrrou, M.


OBJECTIVES: To investigate if skewed X-chromosome inactivation (XCI) is associated with unexplained recurrent miscarriage (RM) in Greek women. METHODS: This was a prospective case-control study. A methylation-sensitive assay was used to investigate the X-inactivation pattern of women with unexplained RM and controls. RESULTS: Fifty-six of the 74 patients (75.7%) and 55 of 80 controls (68.8%) were informative. Among the informative cases, 6/56 (10.7%) women showed extreme XCI (>90%) and among the informative controls, 2/55 (3.6%) showed extreme XCI. CONCLUSIONS: In the present study, women with unexplained RM showed a statistically nonsignificant increase in skewed XCI prevalence (10.7%) compared with control women (3.6%; p = 0.271).
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Abortion, Habitual/*genetics,Adult,Case-Control Studies,Female,Greece,Heterozygote,Humans,Male,Odds Ratio,Polymerase Chain Reaction,Pregnancy,Prospective Studies,Receptors, Androgen/genetics,*X Chromosome Inactivation
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18239
ISSN: 1421-9964
Link: http://www.ncbi.nlm.nih.gov/pubmed/18417978
http://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000116741
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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