Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers (Journal article)

Gogali, A./ Charalabopoulos, K./ Zampira, I./ Konstantinidis, A. K./ Tachmazoglou, F./ Daskalopoulos, G./ Constantopoulos, S. H./ Dalavanga, Y.


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dc.contributor.authorGogali, A.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorZampira, I.en
dc.contributor.authorKonstantinidis, A. K.en
dc.contributor.authorTachmazoglou, F.en
dc.contributor.authorDaskalopoulos, G.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorDalavanga, Y.en
dc.date.accessioned2015-11-24T18:51:06Z-
dc.date.available2015-11-24T18:51:06Z-
dc.identifier.issn1931-3543-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/18200-
dc.rightsDefault Licence-
dc.subjectBronchoscopyen
dc.subjectCadherins/*blooden
dc.subjectCarcinoma, Non-Small-Cell Lung/blood/diagnosisen
dc.subjectDiagnosis, Differentialen
dc.subjectE-Selectin/*blooden
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHumansen
dc.subjectIntercellular Adhesion Molecule-1/*blooden
dc.subjectLung Neoplasms/*blood/diagnosisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectSmall Cell Lung Carcinoma/blood/diagnosisen
dc.subjectTomography, X-Ray Computeden
dc.subjectTumor Markers, Biological/blooden
dc.titleSoluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkersen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primary10.1378/chest.10-0157-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20495107-
heal.identifier.secondaryhttp://chestjournal.chestpubs.org/content/138/5/1173.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2010-
heal.abstractBACKGROUND: Altered levels of circulating adhesion molecules found in several carcinomas, including lung cancer, reflect local loss of diffusion barriers and tumor volume and can be potentially used as biomarkers. In the present study, we investigated the role of soluble E-cadherin (sE-cad), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E-selectin (sE-sel) as biomarkers in lung cancer. METHODS: Sixty-two patients with recently diagnosed lung cancer, 42 with small cell lung cancer (SCLC), and 20 with non-small cell lung cancer (NSCLC), as well as 29 healthy volunteers were enrolled. Blood samples were collected at the time of diagnosis and measurement of soluble adhesion molecules in the serum samples was performed by enzyme-linked immunoassay using monoclonal antibodies against E-cadherin, E-selectin, and ICAM-1. RESULTS: Serum levels of sE-cad, sE-sel, and sICAM-1 in both SCLC and NSCLC were significantly elevated compared with control subjects (P < .001). In addition, patients with SCLC or NSCLC with distant metastasis had a marked increase of sE-Cad (P < .001), but no such correlation with sE-sel and sICAM-1 was found. CONCLUSIONS: Our findings suggest that sE-cad, sE-sel, and sICAM-1 have an adjunctive diagnostic role in lung cancer. Furthermore, sE-cad may also have a prognostic role and could be a useful biomarker in the prediction of lung cancer outcome.en
heal.journalNameChesten
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
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