Spontaneous splenic haematoma in a multiple myeloma patient receiving pegfilgrastim support (Journal article)

Hatzimichael, E./ Benetatos, L./ Stebbing, J./ Kapsali, E./ Panayiotopoulou, S./ Bourantas, K. L.


Growth factors are a significant advance in the supportive care of patients with cancer with a wide range of indications. Frequent side effects of G-CSF include bone pain, headache, fatigue and nausea. We report a case of subcapsular splenic haematoma following pegfilgrastim administration in a 65-year old patient with multiple myeloma. Proposed mechanisms accounting for splenic enlargement include extramedullary haemopoiesis, intrasplenic infiltration by mature and immature myeloid cells and intrasplenic stem cell homing and proliferation. The risk of spontaneous splenic rupture is difficult to quantify. Physicians should be aware of this life-threatening condition and early diagnosis can be difficult since anemia and splenomegaly are common findings in haematologic patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Anemia/etiology,Female,Granulocyte Colony-Stimulating Factor/*adverse effects/therapeutic use,Humans,Multiple Myeloma/complications/*drug therapy,Recombinant Proteins,Rupture, Spontaneous/etiology/surgery,Splenic Rupture/blood/*etiology/surgery
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18148
ISSN: 0141-9854
Link: http://www.ncbi.nlm.nih.gov/pubmed/17105496
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2257.2006.00819.x/asset/j.1365-2257.2006.00819.x.pdf?v=1&t=h2boq3so&s=5982923b9482bd73529e0b584d65ae85ebcd7796
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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