Statin therapy is associated with reduced total and cardiovascular mortality after coronary artery bypass grafting surgery (Journal article)

Papathanasiou, A./ Toumpoulis, I. K./ Milionis, H. J./ Kalantzi, K./ Katsouras, C. S./ Goudevenos, J.

OBJECTIVE: In an observational study, we evaluated the association between postoperative statin therapy and long-term mortality among patients undergoing a first-ever coronary artery bypass grafting (CABG) surgery. METHODS: In an outpatient clinic setting, we assessed 1869 consecutive patients (age 58.7+/-9.6 years; 1657 men), who survived the 1st month after a first-ever CABG, within a 17-year period. Cox proportional hazard analysis was used to calculate the adjusted hazard ratios (adjusting for age, smoking, the presence of hypertension, diabetes mellitus, lipid profile at the time of the procedure, vessel disease, number and kind of grafts used, and concomitant treatment) for patients receiving statin treatment during follow-up and adjusted Kaplan-Meier survival curves were constructed. RESULTS: During a 9345 patient-years follow-up, 48% of the patients were on a statin. In a total of 222 deaths, 80.6% were because of cardiovascular causes. Total and cardiovascular mortality were significantly reduced in patients receiving statin therapy [adjusted hazard ratio, 0.48 (95% confidence interval, 0.28-0.82); P=0.007), and 0.43 (95% confidence interval, 0.23-0.80); P=0.007, respectively]. The estimated 16-year Kaplan-Meier survival curves diverged at 2 years and thereafter. CONCLUSION: Taking into account the potential limitations of observational data, statin treatment postoperatively is associated with a 50% reduction in total and cardiovascular mortality in patients undergoing a first-ever CABG.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Aged,Cardiovascular Diseases/etiology/mortality/*prevention & control,Coronary Artery Bypass/adverse effects/*mortality,Coronary Artery Disease/*drug therapy/mortality/*surgery,Female,Greece/epidemiology,Humans,Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use,Kaplan-Meier Estimate,Male,Middle Aged,Postoperative Care,Proportional Hazards Models,Retrospective Studies,Risk Assessment,Time Factors,Treatment Outcome
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/18126
ISSN: 1473-5830
Link: http://www.ncbi.nlm.nih.gov/pubmed/19005297
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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