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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kyros, L. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.contributor.author | Male, L. | en |
| dc.contributor.author | Hursthouse, M. B. | en |
| dc.contributor.author | Verginadis,, II | en |
| dc.contributor.author | Gouma, E. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.date.accessioned | 2015-11-24T18:50:23Z | - |
| dc.date.available | 2015-11-24T18:50:23Z | - |
| dc.identifier.issn | 1687-479X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18062 | - |
| dc.rights | Default Licence | - |
| dc.title | Structural properties, cytotoxicity, and anti-inflammatory activity of silver(I) complexes with tris(p-tolyl)phosphine and 5-chloro-2-mercaptobenzothiazole | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | 10.1155/2010/386860 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20379345 | - |
| heal.identifier.secondary | http://downloads.hindawi.com/journals/bca/2010/386860.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | The synthesis and characterization of the silver(I) chloride complex of formula {[AgCI(CMBZT)(TPTP)(2)] . (MeOH)} (1) (CMBZT = 5-chloro-2-mercaptobenzothiazole, TPTP = tris(p-tolyl)phosphine) is described. Also the structure of the hydrate derivative {[AgCI(TPTP)(3)] . (0.5 . H(2)O)} (2) of the corresponding known anhydrous silver complex (Zartilas et al., 2009), and the polymorph 3 of the known [AgI(TPTP)(3)] complex (Zartilas et al., 2009) were determined and compared with the known ones. In addition, the structure of the known one silver(I) cluster {[AgI(TPTP)](4)} (4) (Meijboom et al., 2009) was re-determined at 120(2) K and possible Ag-Ag interactions were analyzed. The compounds 1-4 were characterized by X-ray crystallography at r.t (1) and 120 K (2-4). All these complexes and {[(Et(3)NH)(+)](2) . [Ag(6)(mu(3)-Hmna)(4)(mu(3)-mna)(2)](2-) . (DMSO)(2) . (H(2)O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity. The in vitro testing of cytotoxic activity of 1-5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays. The flow cytometry assay for complex 1 and showed that at 15 muM of 1, 62.38% of LMS cells undergo apoptosis, while 7% of LMS cells undergo cell necrosis. The antitumor activity of 3 is comparable with that of its reported polymorph (Zartilas et al., 2009). The anti-inflammatory, activity of complexes 1-3 and 5 was also studied. The activity towards cell viability was 2 > 3 > 5 > 1 > 4, while the order of the inhibitory activity in cell growth proliferation follows the order, 2 > 3 > 1 > 4 > 5. The anti-inflammatory activity on the other hand is 1 > 2 > 5 > cdots, three dots, centered >3. | en |
| heal.journalName | Bioinorg Chem Appl | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kyros-2010-Structural propertie.pdf | 1.87 MB | Adobe PDF | View/Open |
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