Suppression of the acquisition of conditioned avoidance behavior in the rat by 3-methylcholanthrene (Journal article)

Konstandi, M./ Pappas, P./ Johnson, E./ Lecklin, A./ Marselos, M.

Repeated treatment with 3-methylcholanthrene (MC; 25 mg/kg body weight, i.p., two times per week, 1 month) in both male and female Wistar rats resulted in decreased performance in two sessions of a two-way active avoidance procedure. In addition, young male rats that were injected repeatedly with MC prepubertally showed diminished acquisition in conditioned avoidance behavior during both sessions. It appears that MC can alter both avoidance acquisition and retention test performance in adult male and female rats, as well as in young males. This effect was not associated with alterations in sex hormone levels. The findings of this study suggest a significant influence of MC on specific mental functions.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Avoidance Learning/*drug effects,Carcinogens/*toxicity,Conditioning (Psychology)/drug effects,Estradiol/blood,Female,Male,Methylcholanthrene/*toxicity,Rats,Rats, Wistar,Retention (Psychology)/drug effects,Testosterone/blood
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/17985
ISSN: 0091-3057
Link: http://www.ncbi.nlm.nih.gov/pubmed/9130288
http://ac.els-cdn.com/S0091305796004078/1-s2.0-S0091305796004078-main.pdf?_tid=bfe5844c2073bd169960bd7fa891b559&acdnat=1333002445_54c3be13fb1ae684470dd569fb33c5f8
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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