Surgical repair versus medical treatment of varicocele in the rat: pharmacological manipulation of the varicocelized testicle (Journal article)

Sofikitis, N./ Takahashi, C./ Kadowaki, H./ Okazaki, T./ Nakamura, I./ Shimamoto, T./ Saeki, H./ Miyagawa, I.

Human chorionic gonadotropin, kallikrein, indomethacin, and hydralazine were administered to different groups of varicocelized rats, while surgical repair of the varicocele was performed in another group of rats. The effects of conservative and surgical treatment on epididymal sperm content and motility, the weights of the testes, epididymis, and male accessory genital glands, and fertility were compared between each group and a sham-treated group of rats. Surgical repair significantly improved all the evaluated parameters and all the conservative regimens, except hydralazine, resulted in a significant improvement in most parameters. Our results indicate that stimulation of the Leydig or/and Sertoli cells of a varicocelized testicle can counteract some of the detrimental consequences of the varicocele itself.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Animals,Body Temperature/drug effects,Chorionic Gonadotropin/pharmacology,Epididymis/pathology,Fertility/drug effects,Hydralazine/pharmacology,Indomethacin/pharmacology,Infertility, Male/drug therapy/etiology/surgery,Kallikreins/pharmacology,Male,Organ Size/drug effects,Prostate/pathology,Rats,Rats, Wistar,Sperm Count/drug effects,Sperm Motility/drug effects,Testis/*drug effects/pathology/physiopathology,Varicocele/pathology/physiopathology/surgery/*therapy
ISSN: 0302-2838
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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