Myocardial perfusion imaging with (99) Tc-m-tetrofosmin SPECT in breast cancer patients that received postoperative radiotherapy: a case-control study (Journal article)

Sioka, C./ Exarchopoulos, T./ Tasiou, I./ Tzima, E./ Fotou, N./ Capizzello, A./ Ragos, V./ Tsekeris, P./ Fotopoulos, A.

Purpose: To evaluate the cardiac toxicity of radiotherapy (RT) in breast cancer (BC) patients employing myocardial perfusion imaging (MPI) with Tc-99 m Tetrofosmin - single photon emission computer tomography (T-SPECT). Materials and methods: We studied 46 BC female patients (28 patients with left and 18 patients with right BC) treated with postoperative RT compared to a control group of 85 age-matched females. The median time of RT to SPECT was 40 months (6-263). Results: Abnormalities in the summed stress score (SSS) were found in 54% of left BC patients, 44.4% of right BC patients, and 32.9% of controls. In left BC patients there were significantly more SSS abnormalities compared to controls (4.0 +/- 3.5 vs 2.6 +/- 2.0, p = 0.05) and possible trend of increased abnormalities of right BC patients (3.7 +/- 3.0 vs 2.6 +/- 2.0, p = 0.14). Multiple regression analysis showed more abnormalities in the MPI of left BC patients compared to controls (SSS, p = 0.0001); Marginal toxicity was also noted in right BC patients (SSS, p = 0.045). No additional toxicity was found in patients that received adjuvant cardiotoxic chemotherapy. All T-SPECT abnormalities were clinically silent. Conclusion: The study suggests that radiation therapy to BC patients result in MPI abnormalities but without apparent clinical consequences.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: myocardium,spect,breast cancer,radiotherapy,ischemic-heart-disease,radiation-therapy,adjuvant radiotherapy,randomized-trials,nuclear-medicine,cardiac toxicity,morbidity,damage,mortality,risk
ISSN: 1748-717X
Link: <Go to ISI>://000297282900001
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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