Heterotopic ossification after total hip arthroplasty (THA) in congenital hip disease: comparison of two different prophylactic protocols (Journal article)

Pakos, E. E./ Stafilas, K. S./ Politis, A. N./ Tsekeris, P. G./ Mitsionis, G./ Xenakis, T. A.


We aimed to evaluate retrospectively the efficacy of combined postoperative radiotherapy and indomethacin compared to indomethacin alone for the prevention of heterotopic ossification (HO) in high-risk patients with congenital disease of hip (CDH) undergoing total hip arthroplasty (THA). Fifty-five patients received indomethacin alone (Group A), while 44 patients received the combined protocol (Group B). Patients a parts per thousand yen55 years were enrolled in Group B and those younger than 55 years in Gro up A. Patients were evaluated radiologically for the pre sence of HO 6 months after the operation. The incidence of HO in Group A was 34.5% (95% confidence interval 22.2-48.6%), while the respective incidence in Group B patients was 27.3% (95% CI 15.0-42.8%). The difference was not statistically significant (p=0.5). No significant treatment-related side effects were reported. This is the first study evaluating the impact of HO prophylaxis in an immiscible population of patients with secondary arthritis due to CDH undergoing THA. Further future randomised evidence is required in order to ascertain the observed trend towards improved efficacy of the combined protocol for HO development.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: congenital hip disease,total hip arthroplasty,heterotopic ossification,radiotherapy,indomethacin,high-risk patients,bone-formation,ectopic ossification,predisposing factors,radiation-therapy,prevention,indomethacin,radiotherapy,replacement,irradiation
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/16047
ISSN: 1699-048X
Link: <Go to ISI>://000263511800009
http://link.springer.com/content/pdf/10.1007%2Fs12094-009-0322-1.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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