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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/13913
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dc.contributor.authorBaltogiannis, G. G.en
dc.contributor.authorTsalikakis, D. G.en
dc.contributor.authorMitsi, A. C.en
dc.contributor.authorHatzistergos, K. E.en
dc.contributor.authorElaiopoulos, D.en
dc.contributor.authorFotiadis, D. I.en
dc.contributor.authorKyriakides, Z. S.en
dc.contributor.authorKolettis, T. M.en
dc.date.accessioned2015-11-24T17:33:57Z-
dc.date.available2015-11-24T17:33:57Z-
dc.identifier.issn0008-6363-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/13913-
dc.rightsDefault Licence-
dc.subjectarrhythmia (mechanisms)en
dc.subjectendothelinsen
dc.subjectinfarctionen
dc.subjectcoronary-artery occlusionen
dc.subjectendogenous endothelinen
dc.subjectischemic arrhythmiasen
dc.subjectanesthetized ratsen
dc.subjectantagonisten
dc.subjecthearten
dc.subjectreperfusionen
dc.subjectbq-123en
dc.subjectsizeen
dc.subjectdogsen
dc.titleEndothelin receptor - A blockade decreases ventricular arrhythmias after myocardial infarction in ratsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.cardiores.2005.04.020-
heal.identifier.secondary<Go to ISI>://000231183500011-
heal.identifier.secondaryhttp://cardiovascres.oxfordjournals.org/content/67/4/647.full.pdf-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.publicationDate2005-
heal.abstractObjective: Endothelin-1 (ET-1) production increases during acute myocardial infarction (MI) and may contribute to the genesis of ventricular tachycardia, (VT) and ventricular fibrillation (VF). However, the antiarrhythmic effects of ET-I receptor blockade, examined shortly after MI, have been debated. In the present study, we examined the effects of such treatment on VT/VF during the first 24 h post-MI. Methods: Thirty-five Wistar rats (223 +/- 22 g) were randomly allocated to either the ET-I receptor-A (ETA) antagonist BQ-123 (0.4 mg/kg, BQ-123 group, n=17), or normal saline (control group, n=18) and were subjected to coronary artery ligation. A single-lead electrocardiogram was continuously recorded for 24 h post-MI, using an implanted telemetry system, and episodes of VT/VF were analyzed. Monophasic action potential (MAP) recordings were obtained from the left (LV) and right (RV) ventricular epicardium at baseline, 5 min after treatment and 24 h post-MI. Results: There were 15.94 +/- 19.35 episodes/h/rat of VT/VF in the control group and 1.66 +/- 2.22 in the BQ-123 group (p=0.010), resulting in a lower (p=0.030) arrhythmic mortality in treated animals. The mean episode duration was 7.40 +/- 7.16 s for the control group and 2.30 +/- 1.37 s for the BQ-123 group (p=0.011). The maximum decrease in VT/VF was observed during the 1st, 5th and 6th hours post-MI. In the control group, LV MAP duration increased 24 It post-MI, displaying an increased beat-to-beat variation, but remained unchanged in the BQ-123 group. Conclusion: Acute ETA blockade reduces the incidence of VT/VF during the first 24-h post-MI in the rat, through a decrease in the dispersion of repolarization. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.en
heal.publisherElsevieren
heal.journalNameCardiovasc Resen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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