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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tzotzas, T. | en |
| dc.contributor.author | Filippatos, T. D. | en |
| dc.contributor.author | Triantos, A. | en |
| dc.contributor.author | Bruckert, E. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Kiortsis, D. N. | en |
| dc.date.accessioned | 2015-11-24T16:57:14Z | - |
| dc.date.available | 2015-11-24T16:57:14Z | - |
| dc.identifier.issn | 0939-4753 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10555 | - |
| dc.rights | Default Licence | - |
| dc.subject | lp-pla(2) | en |
| dc.subject | weight loss | en |
| dc.subject | ldl phenotype | en |
| dc.subject | very low-density lipoprotein | en |
| dc.subject | small dense ldl | en |
| dc.subject | activating-factor-acetylhydrolase | en |
| dc.subject | coronary-heart-disease | en |
| dc.subject | c-reactive protein | en |
| dc.subject | middle-aged men | en |
| dc.subject | risk-factors | en |
| dc.subject | artery-disease | en |
| dc.subject | human plasma | en |
| dc.subject | insulin-resistance | en |
| dc.subject | dense ldl | en |
| dc.subject | follow-up | en |
| dc.title | Effects of a low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity in healthy obese women | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.numecd.2007.04.004 | - |
| heal.identifier.secondary | <Go to ISI>://000259537600004 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0939475307000804/1-s2.0-S0939475307000804-main.pdf?_tid=e867f6f8bdbee0b9d21750359b55e84a&acdnat=1333112375_f84232640d1f6cdc65053d2f792b575f | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2008 | - |
| heal.abstract | Introduction: Platelet-activating factor acetylhydrolase (PAF-AH or Lp-PLA(2)) is a Ca2+-independent phospholipase A(2) primarily associated in plasma with low density lipoproteins (LDL), especially with small dense LDL (sdLDL) particles. Increased plasma Lp-PLA(2) levels have been associated with increased cardiovascular risk in large clinical trials. Aim: To assess the effects of weight loss on Lp-PLA(2) activity and to examine the association of Lp-PLA(2) activity changes with the alterations of sdLDL, the primary carrier of Lp-PLA(2) in plasma. Methods: Twenty-eight obese, non-diabetic women participated in a weight reduction program. Anthropometric parameters were assessed and parameters of glucose metabolism, lipid profile, Lp-PLA(2) activity, and LDL phenotype (using a 3% polyacrylamide get-tube etectrophoresis method), were determined at baseline and after 4 months of weight loss. Results: A 10% diet-induced weight toss resulted in significant improvement in most parameters of lipid and glucose metabolism. Moreover, Lp-PLA(2) activity was significantly reduced (-10.2%, p < 0.01). Mean LDL particle diameter did not change after the weight toss program. The cholesterol levels of very tow-density lipoprotein (VLDL) and large-buoyant LDL particles were significantly reduced, but neither the cholesterol levels of sdLDL particles nor the % proportion of the sdLDL-cholesterol over the total LDL-cholesterol were changed after the intervention program. Interestingly, the changes in Lp-PLA(2) activity were correlated with the changes of VLDL-chotesterol (r = 0.39, p < 0.05), but not with the changes of anthropometric or other lipid variables. Conclusions: A low-calorie diet associated with weight toss in obese women resulted in the significant reduction of the plasma levels of Lp-PLA(2), the potentially new predictor for incident atherosclerotic disease. (C) 2007 Elsevier B.V. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | Nutrition Metabolism and Cardiovascular Diseases | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tzotzas-2008-Effects of a low-cal.pdf | 189.36 kB | Adobe PDF | View/Open Request a copy |
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