Dose-dependent Effect of Rosuvastatin Treatment on HDL-subfraction Phenotype in Patients With Primary Hyperlipidemia (Journal article)

Kostapanos, M. S./ Milionis, H. J./ Filippatos, T. D./ Christogiannis, L. G./ Bairaktari, E. T./ Tselepis, A. D./ Elisaf, M. S.

Although the raising effect of rosuvastatin on high-density lipoprotein cholesterol is well-established, there is a paucity of data regarding the effect of this statin on the high-density lipoprotein subfraction phenotype. A total of 150 participants without evidence of cardiovascular disease were randomized to therapeutic lifestyle modification (nonstatin-treated group) or to therapeutic lifestyle modification plus rosuvastatin at 10 mg/d (RSV10 group) or 20 mg/d (RSV20 group). We assessed the effect of rosuvastatin on the cholesterol mass of high-density lipoprotein subfractions at baseline as well as after 12 weeks post-treatment. Rosuvastatin treatment close-dependently increased the high-density lipoprotein cholesterol (3.4% vs 5.3% in the RSV10 and RSV20 groups, respectively, P = .02). A dose-related rosuvastatin-induced increase in the cholesterol concentration of large high-density lipoprotein particles was also noted (by 11.4% in RSV10 group vs 22.0% in the RSV20 group, P = .01). Rosuvastatin treatment increases the high-density lipoprotein cholesterol by increasing the cholesterol mass only of the larger high-density lipoprotein particles in a dose-dependent manner.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: hdl subfractions,paraoxonase-1,lipoprotein-associated phospholipase a(2),rosuvastatin,activating-factor-acetylhydrolase,coronary-heart-disease,lipoprotein subfractions,subpopulation profile,hypolipidemic drugs,phospholipase a(2),human plasma,dense ldl,atorvastatin,cholesterol
ISSN: 1074-2484
Link: <Go to ISI>://000263489900001
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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