Crystal structure and antitumor activity of the novel zwitterionic complex of tri-n-Butyltin(IV) with 2-thiobarbituric acid (Journal article)

Balas, V. I./ Hadjikakou, S. K./ Hadjiliadis, N./ Kourkoumelis, N./ Light, M. E./ Hursthouse, M./ Metsios, A. K./ Karkabounas, S.


A novel tri-n-butyl(IV) derivative of 2-thiobarbituric acid (HTBA) of formula [(n-Bu)(3)Sn(TBA) center dot H(2)O] ( 1) has been synthesized and characterized by elemental analysis and (119)Sn-NMR and FT-IR spectroscopic techniques. The crystal structure of complex 1 has been determined by single crystal X-ray diffraction analysis at 120( 2) K. The geometry around Sn( IV) is trigonal bipyramidal. Three n-butyl groups and one oxygen atom from a deprotonated 2-thiobarbituric ligand are bonded to the metal center. The geometry is completed with one oxygen from a water molecule. Compound 1 exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a] pyrene) carcinogenesis. In addition, the inhibition caused by 1, in the rate of lipoxygenase (LOX) catalyzed oxidation reaction of linoleic acid to hyperoxolinoleic acid, has been also kinetically and theoretically studied. The results are compared to that of cisplatin. Copyright (c) 2008.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: organotin(iv) complexes,donor ligands,derivatives,c-13
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/10249
ISSN: 1565-3633
Link: <Go to ISI>://000255640300001
http://downloads.hindawi.com/journals/bca/2008/654137.pdf
Publisher: Hindawi Publishing Corporation
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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